x !
Archived Curricula Guide 2017–2019
Curricula Guide is archieved. Please refer to current Curricula Guides
BIO4450 High-throughput data analysis 5 ECTS
Organised by
Master's Degree Programme in Bioinformatics
Preceding studies
Compulsory:
BIO4440 or equivalent knowledge required.
Corresponding course units in the curriculum
BioMediTech
Curricula 2015 – 2017

Keywords

Strategic themes: Internationalisation, Responsible conduct of research

Learning outcomes

After the course, the student can:
- compare sequencing and microarray technologies used in high-throughput analysis and choose suitable ones for the analysis required.
- explain the principles of measurement technologies covered and how various inherent errors and biases of the measurement techniques affect the analysis.
- take raw data from high-throughput experiments and preprocess and normalize the data for analysis if needed using standard tools.
- apply common methods and algorithms, including state-of-the-art, to extract information from high-throughput measurement data, particularly in the context of RNA-seq and ChIP-seq data.
- discuss the statistical principles underlying the data analysis methods above and identify the benefits and weaknesses of each method.
- select suitable algorithms for the analysis and justify the choice.
- build data analysis pipelines for microarray and sequencing data analysis.

Contents

- High-throughput sequencing and microarray technologies
- Short read alignment, including Burrows-Wheeler and indexing
- Advanced clustering, including k-means, consensus clustering and biclustering
- Statistical testing for high-throughput data
- Gene set enrichment analysis
- Feature detection
- Multiple testing problem, including False discovery rate (FDR) estimation

Modes of study

Option 1
Available for:
  • Degree Programme Students
  • Other Students
  • Open University Students
  • Doctoral Students
  • Exchange Students
Participation in course work 
In English
Exercise(s) 
In English

Evaluation

Numeric 1-5.

Belongs to following study modules

Faculty of Medicine and Life Sciences
2018–2019
Teaching
Faculty of Medicine and Life Sciences